Solution-Results of a free radioimmunoassay

Allison is a 32-year-old female with the following symptoms: dismal facial expression; droopy eyelids; swollen face and per orbital areas; thin, dry hair; dry, crusty skin; evidence of intellectual impairment; lethargy; a change of personality; bradycardia (59 b/min); blood pressure of 93/72; anemia (hematocrit 28); enlarged heart (upon radiological exam); constipation, and hypothermia. Plasma concentrations of total and free T4 and T3 include:

	T4	T3 Save your time - order a paper! Get your paper written from scratch within the tight deadline. Our service is a reliable solution to all your troubles. Place an order on any task and we will take care of it. You won’t have to worry about the quality and deadlines Order Paper Now
Total	3.1 µg/dL	0.15 ng/dL
Free	0.5 ng/dL	0.02 ng/dL

Elevated TSH levels were seen from the results of a Free Radioimmunoassay (RIA) of peripheral blood. A TSH stimulation test did not increase the output of thyroid hormones from the thyroid gland.

• What endocrine organ is involved in this situation?
• Is this a primary or secondary disorder? Explain.
• Describe the feedback loop involved. Signify if there is an increased or decreased TSH level.
• List several defects or disorders that could cause these symptoms.
• Would you expect to find a palpable goiter? Why?

Describe an appropriate treatment for this patient.